水合氯醛
  • 化学数据
CAS号 302-17-0 货号 BCP31225
中文名 水合氯醛
英文名 Chloral hydrate
中文别名
英文别名 2,2,2-Trichloroethane-1,1-diol;Trichloroacetaldehyde hydrate;
分子式 C2H3Cl3O2 分子量 165.4
  • 用途
生物活性 Chloral Hydrate is a synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system.
  • 引用文献
Dexmedetomidine protects against endothelial injury in septic rats induced by cecal ligation and puncture by decreasing angiopoietin 2 and increasing vascular endothelial cadherin levels

购于瀚香生物(Biochempartner)的水合氯醛(CAS:302-17-0)被引用

结构式

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