丁酸钠
| CAS号 | 156-54-7 | 货号 | BCP31813 |
| 中文名 | 丁酸钠 | ||
| 英文名 | Sodium Butyrate | ||
| 中文别名 | 正丁酸钠; | ||
| 英文别名 | Butyric acid sodium salt; | ||
| 分子式 | C4H7NaO2 | 分子量 | 110.09 |
| 生物活性 | Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling. | ||
| 信号通路 | Cell Cycle/DNA Damage Others Pathway | ||
| 靶 点 | Autophagy HDAC | ||
结构式
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