LY-3381916
  • 化学数据
CAS号 2166616-75-5 货号 BCP33269
中文名 LY-3381916
英文名 LY-3381916
中文别名
英文别名 LY 3381916; LY 3381916; IDO1-IN-5;
分子式 C23H25FN2O3 分子量 396.46
  • 用途
生物活性 LY-3381916, also known as IDO1-IN-5, is a potent, selective and brain penetrated DO1 inhibitor. LY3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
信号通路 Protease/Metabolic Enzyme 
靶 点 IDO 

结构式

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