Indibulin
CAS号 | 204205-90-3 | 货号 | BCP33949 |
中文名 | Indibulin | ||
英文名 | Indibulin | ||
中文别名 | |||
英文别名 | ZIO 301;D 24851;ZIO301;D24851;ZIO-301;D-24851; | ||
分子式 | C22H16ClN3O2 | 分子量 | 389.83 |
生物活性 | Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines. Check for active clinical trials or closed clinical trials using this agent. | ||
信号通路 | Cell Cycle/DNA Damage | ||
靶 点 | Microtubule |
结构式

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