FTI-276
| CAS号 | 170006-72-1 | 货号 | BCP37170 |
| 中文名 | FTI-276 | ||
| 英文名 | FTI-276 | ||
| 中文别名 | |||
| 英文别名 | FTI276; FTI 276; | ||
| 分子式 | C21H27N3O3S2 | 分子量 | 433.59 |
| 生物活性 | FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | FTase | ||
结构式
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