阿美替尼
| CAS号 | 1899921-05-1 | 货号 | BCP38312 |
| 中文名 | 阿美替尼 | ||
| 英文名 | Almonertinib | ||
| 中文别名 | |||
| 英文别名 | HS-10296; HS 10296; HS10296; | ||
| 分子式 | C30H35N7O2 | 分子量 | 525.64 |
| 生物活性 | Almonertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. | ||
| 上下游产品 | 2134096-03-8（阿美替尼盐酸盐） 2134096-06-1（阿美替尼甲磺酸盐） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR | ||
结构式
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