SD-36
| CAS号 | 2429877-44-9 | 货号 | BCP40409 |
| 中文名 | SD-36 | ||
| 英文名 | SD-36 | ||
| 中文别名 | |||
| 英文别名 | SD 36; SD-36; | ||
| 分子式 | C59H62F2N9O12P | 分子量 | 1158.17 |
| 生物活性 | SD-36 is a PROTAC Degrader of STAT3 Protein. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over other STAT members. Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells. SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis. SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | PROTAC | ||
结构式
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