美拉沙星
| CAS号 | 91188-00-0 | 货号 | BCP42636 |
| 中文名 | 美拉沙星 | ||
| 英文名 | Merafloxacin | ||
| 中文别名 | |||
| 英文别名 | CI 934; CI-934; CI934; | ||
| 分子式 | C19H23F2N3O3 | 分子量 | 379.41 |
| 生物活性 | Merafloxacin is a fluoroquinolone antibacterial, which was also identified as a −1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting −1 PRF as an effective antiviral strategy for SARS-CoV-2. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | Antibiotic SARS CoV | ||
结构式
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