AT-511
  • 化学数据
CAS号 1998705-64-8 货号 BCP43134
中文名 AT-511
英文名 AT-511
中文别名
英文别名 AT511; AT 511; Bemnifosbuvir;
分子式 C24H33FN7O7P 分子量 581.53
  • 用途
生物活性 AT-511, the free base form of AT-527, against several coronaviruses, including SARS-CoV-2, the causative agent of COVID-19. In normal human airway epithelial (HAE) cell preparations, the average concentration of AT-511 required to inhibit replication of SARS-CoV-2 by 90% (EC90) was 0.5 µM, very similar to the EC90 for AT-511 against HCoV-229E, HCoVOC43 and SARS-CoV in Huh-7 cells. No cytotoxicity was observed for AT-511 in any of the antiviral assays up to the highest concentration tested (100 µM). Surprisingly, AT-511 was 30-fold less active against MERS-CoV.
信号通路 Microbiology/Virology 
靶 点 SARS CoV 

结构式

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