CHR-3996
| CAS号 | 1235859-13-8 | 货号 | BCP44113 |
| 中文名 | CHR-3996 | ||
| 英文名 | CHR-3996 | ||
| 中文别名 | |||
| 英文别名 | CHR3996;CHR 3996; | ||
| 分子式 | C21H20FN5O2 | 分子量 | 393.41 |
| 生物活性 | CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | HDAC | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！