AS2676293

Chemical Properties

CAS No.	1393999-79-5	Cat. No.	BCP46977
Name	AS2676293
Synonyms	AS-2676293;AS 2676293;
Formula	C18H14F4N4O	M. Wt	378.33

Biological Activity

Description	AS2676293 is a small molecule RANKL inhibitor that is effective in treating mouse metastasis in mouse models. AS2676293 is orally bioavailable and inhibited bone metastasis of human breast cancer cells (MDA-MB-231-5a-D-Luc2) and tumor-induced osteolysis. In transwell assays, AS2676293 inhibited bone metastasis of B16F10, a murine cell line that is known not to trigger osteoclast activation. AS2676293 has potential for development as a therapy for treating bone metastasis through the inhibition of both osteoclast bone resorption and tumor migration to bone.

Description

AS2676293 is a small molecule RANKL inhibitor that is effective in treating mouse metastasis in mouse models. AS2676293 is orally bioavailable and inhibited bone metastasis of human breast cancer cells (MDA-MB-231-5a-D-Luc2) and tumor-induced osteolysis. In transwell assays, AS2676293 inhibited bone metastasis of B16F10, a murine cell line that is known not to trigger osteoclast activation. AS2676293 has potential for development as a therapy for treating bone metastasis through the inhibition of both osteoclast bone resorption and tumor migration to bone.

Structure

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.

For product details of different batches, please contact our Customer

Service & Tech Support:orders@biochempartner.com

Website:www.biochempartner.com

Products are for research use only and not for human use. We do not sell to patients.