AS2676293

化学数据

CAS号	1393999-79-5	货号	BCP46977
中文名	AS2676293
英文名	AS2676293
中文别名
英文别名	AS-2676293;AS 2676293;
分子式	C18H14F4N4O	分子量	378.33

用途

生物活性	AS2676293 is a small molecule RANKL inhibitor that is effective in treating mouse metastasis in mouse models. AS2676293 is orally bioavailable and inhibited bone metastasis of human breast cancer cells (MDA-MB-231-5a-D-Luc2) and tumor-induced osteolysis. In transwell assays, AS2676293 inhibited bone metastasis of B16F10, a murine cell line that is known not to trigger osteoclast activation. AS2676293 has potential for development as a therapy for treating bone metastasis through the inhibition of both osteoclast bone resorption and tumor migration to bone.

生物活性

AS2676293 is a small molecule RANKL inhibitor that is effective in treating mouse metastasis in mouse models. AS2676293 is orally bioavailable and inhibited bone metastasis of human breast cancer cells (MDA-MB-231-5a-D-Luc2) and tumor-induced osteolysis. In transwell assays, AS2676293 inhibited bone metastasis of B16F10, a murine cell line that is known not to trigger osteoclast activation. AS2676293 has potential for development as a therapy for treating bone metastasis through the inhibition of both osteoclast bone resorption and tumor migration to bone.

结构式

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