Lirafugratinib
| CAS号 | 2549174-42-5 | 货号 | BCP49189 |
| 中文名 | Lirafugratinib | ||
| 英文名 | Lirafugratinib | ||
| 中文别名 | |||
| 英文别名 | FGFR2-IN-3;RLY-4008;RLY4008;RLY 4008; | ||
| 分子式 | C28H24FN7O2 | 分子量 | 509.55 |
| 生物活性 | Lirafugratinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FGFR | ||
结构式
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