Befotertinib
| CAS号 | 1835667-63-4 | 货号 | BCP49575 |
| 中文名 | Befotertinib | ||
| 英文名 | Befotertinib | ||
| 中文别名 | |||
| 英文别名 | D-0316;D0316;D 0316; | ||
| 分子式 | C29H32F3N7O2 | 分子量 | 567.61 |
| 生物活性 | Befotertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, befotertinib specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Compared to some other EGFR inhibitors, befotertinib may have therapeutic benefits in tumors with T790M-mediated drug resistance. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR | ||
结构式
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