SC514
| CAS号 | 354812-17-2 | 货号 | BCP21098 |
| 中文名 | SC514 | ||
| 英文名 | SC514 | ||
| 中文别名 | |||
| 英文别名 | SC-514; SC 514;GK 01140;GK01140;GK-01140; | ||
| 分子式 | C9H8N2OS2 | 分子量 | 224.30 |
| 生物活性 | SC514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) (IC50 = 3-12 μM). SC-514 a candidate compound targeting osteoclastogenesis. SC-514 dose-dependently inhibits RANKL-induced osteoclastogenesis with an IC50 of <5μM. At high concentrations, SC-514 (≥12.5μM) induced apoptosis and caspase 3 activation in RAW264.7 cells. Targeting IKKβ by SC-514 presents as a potential treatment for osteoclast-related disorders such as osteoporosis and cancer-induced bone loss. | ||
| 信号通路 | NFκB | ||
| 靶 点 | IκB/IKK | ||
结构式
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