马来酸盐匹杉琼
| CAS号 | 144675-97-8 | 货号 | BCP07678 |
| 中文名 | 马来酸盐匹杉琼 | ||
| 英文名 | Pixantrone Maleate | ||
| 中文别名 | 马来到匹杉琼;匹克生琼马来酸盐; | ||
| 英文别名 | BBR 2778; BBR2778; BBR-2778; Pixantrone; | ||
| 分子式 | C17H19N5O2.2(C4H4O4) | 分子量 | 441.44 |
| 生物活性 | Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Pixantrone is a potentially more effective, less cardiotoxic alternative to doxorubicin for patients with aggressive non-Hodgkin lymphoma (aNHL). | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase | ||
结构式
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