二硫化四乙基秋兰姆
| CAS号 | 97-77-8 | 货号 | BCP07331 |
| 中文名 | 二硫化四乙基秋兰姆 | ||
| 英文名 | Disulfiram | ||
| 中文别名 | 双硫仑;乙醇脱氢酶(ADH); | ||
| 英文别名 | Tetraethylthiuram disulfide;TETD;Antabuse;NSC 190940; NSC190940; NSC-190940; | ||
| 分子式 | C10H20N2S4 | 分子量 | 296.54 |
| 生物活性 | Disulfiram is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. It blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase, thus causing an unpleasant reaction when alcohol is consumed. Disulfiram should be used in conjunction with counseling and support. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness, and other unpleasant symptoms. Several studies have reported that it has antiprotozoal activity, as well. Disulfiram is the subject of research for use in cancer therapy and as a treatment in HIV cure research (to activate the reservoir of HIV-infected resting CD4 cells) . | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ALDH | ||
结构式
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