阿螺旋霉素盐酸盐
| CAS号 | 467214-21-7 | 货号 | BCP22705 |
| 中文名 | 阿螺旋霉素盐酸盐 | ||
| 英文名 | Alvespimycin HCl | ||
| 中文别名 | |||
| 英文别名 | Alvespimycin hydrochloride;17-DMAG hydrochloride; KOS1022; KO-S1022; KOS 1022;BMS 826476;17 DMAG;17DMAG;7-DMAG HCl; | ||
| 分子式 | C32H48N4O8.HCl | 分子量 | 653.21 |
| 生物活性 | Alvespimycin is an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials or closed clinical trials using this agent. | ||
| 信号通路 | Protease/Metabolic Enzyme Cell Cycle/DNA Damage | ||
| 靶 点 | HSP | ||
结构式
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