NSC 133723
| CAS号 | 19741-14-1 | 货号 | BCP02884 |
| 中文名 | NSC 133723 | ||
| 英文名 | NSC 133723 | ||
| 中文别名 | 4-氨基-4-脱氧-10-甲基蝶酸; | ||
| 英文别名 | NSC131463;DAMPA;NSC-131463;Deoxyaminopteroic acid;Methotrexate Impurity E;4-Amino-4-deoxy-10-methylpteroic acid; | ||
| 分子式 | C15H15N7O2 | 分子量 | 325.33 |
| 生物活性 | NSC 131463 is a minor metabolite of methotrexate. It inhibited L1210 cell proliferation in culture (IC50 = 0.3 μM), and prolonged the survival of L1210 leukemic mice (98% increase in lifespan at 120 mg/kg, qdx9). Studies on the interaction of mAPA-HCysA with partially purified mouse liver folyl polyglutamate synthetase revealed that mAPA-HCysA was not a substrate. Hence, the increased dose of mAPA-HCysA required to inhibit tumor growth in vitro and in vivo relative to methotrexate may reflect, in part, the inability of this compound to form non-effluxing polyglutamates. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DHFR | ||
结构式
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