AMG-208
| CAS号 | 1002304-34-8 | 货号 | BCP01384 |
| 中文名 | AMG-208 | ||
| 英文名 | AMG-208 | ||
| 中文别名 | |||
| 英文别名 | AMG208;AMG 208; | ||
| 分子式 | C22H17N5O2 | 分子量 | 383.41 |
| 生物活性 | AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM. [1] Incubation of AMG-208 with rat and human liver microsomes in the presence of NADPH qualitatively yields C6-phenylarene oxidation products as the major metabolites. [1] Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent in | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met | ||
结构式
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