巴拉塞替-HQPA
| CAS号 | 722544-51-6 | 货号 | BCP01736 |
| 中文名 | 巴拉塞替-HQPA | ||
| 英文名 | Barasertib-HQPA | ||
| 中文别名 | |||
| 英文别名 | Defosbarasertib;AZD-2811; AZD 2811; AZD2811; AZD-1152HQPA; AZD 1152HQPA; AZD1152HQPA; AZD1152 HQPA; AZD1152-HQPA; AZD1152HQPA; | ||
| 分子式 | C26H30FN7O3 | 分子量 | 507.56 |
| 生物活性 | Barasertib, previously known as AZD1152-hydroxyquinazoline pyrazol anilide (HQPA), is a potent aurora kinase inhibitor, which is resulted from rapid phosphatase-mediated cleavage of the precursor, AZD1152, in serum following parenteral administration in vivo. It shows inhibitory effects against a broad range of aurora kinases, including aurora A kinase (AKB), aurora B kinase (ABK), and aurora C kinase (ACK) with inhibition constant (Ki) of 1369 nM, 0.36 nM, and 17.0 nM respectively, as well as the FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation. Barasertib has demonstrated anti-tumor activity against a range tumor cell lines including those of leukaemic acute myeloid leukemia (AML) origin. | ||
| 上下游产品 | 722543-31-9（巴拉塞替） | ||
| 信号通路 | Cell Cycle/DNA Damage Epigenetics | ||
| 靶 点 | Aurora | ||
结构式
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