Sepantronium Bromide
| CAS号 | 781661-94-7 | 货号 | BCP01864 |
| 中文名 | Sepantronium Bromide | ||
| 英文名 | Sepantronium Bromide | ||
| 中文别名 | |||
| 英文别名 | YM-155;YM 155;YM155; | ||
| 分子式 | C20H19BrN4O3 | 分子量 | 443.3 |
| 生物活性 | Sepantronium bromide, also known as YM-155, is a small-molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is expressed during embryonal development and is absent in most normal, terminally differentiated tissues; upregulated in a variety of human cancers, its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Survivin | ||
结构式
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