度他雄胺
| CAS号 | 164656-23-9 | 货号 | BCP02344 |
| 中文名 | 度他雄胺 | ||
| 英文名 | Dutasteride | ||
| 中文别名 | |||
| 英文别名 | GI 198745;GI-198745;GI198745; | ||
| 分子式 | C27H30F6N2O2 | 分子量 | 528.53 |
| 生物活性 | Dutasteride inhibits type-1 5AR and type-2 5AR with IC50 of 6 nM and 7 nM, respectively. Dutasteride is 60-fold more potent than Finasteride in its initial Ki versus type 1 5AR and ~5-fold more rapid in inactivating the enzyme.Dutasteride inhibits (3)H-T conversion to (3)H-DHT and, as anticipated, inhibits T-induced secretion of PSA and proliferation in LNCaP cells. Dutasteride also inhibits DHT-induced PSA secretion and cell proliferation with IC50 of 1 μM in LNCaP cells. Dutasteride competes for binding the LNCaP cell AR with an IC50 of 1.5 μM. Dutasteride (10–50 μM) results in enhanced cell death, possibly by apoptosis, in steroid-free medium. Dutasteride reduces cell viability and cell proliferation in androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer(PCa) cell lines. Dutasteride results in overexpressed genes included genes encoding for proteins involved in biosynthesis and metabolism of androgen (HSD17B1;HSD17B3;CYP11B2), androgen receptor and an | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | 5 alpha Reductase | ||
结构式
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