SB743921
CAS号 | 940929-33-9 | 货号 | BCP02471 |
中文名 | SB743921 | ||
英文名 | SB743921 | ||
中文别名 | |||
英文别名 | SB-743921;SB 743921; | ||
分子式 | C31H33N2O3.HCl | 分子量 | 553.53 |
生物活性 | The Ki of SB 743921 for human and mouse KSP is 0.1 nM and 0.12 nM, respectively, while the Ki of SB 743921 for other kinesins including MKLP1, Kin2 is more than 70 μM. SB 743921 blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death. SB-743921 has improved potency over ispinesib in both biochemical and cellular assays. | ||
信号通路 | Cell Cycle/DNA Damage | ||
靶 点 | Kinesin |
结构式

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