WZ4002
| CAS号 | 1213269-23-8 | 货号 | BCP02515 |
| 中文名 | WZ4002 | ||
| 英文名 | WZ4002 | ||
| 中文别名 | |||
| 英文别名 | WZ 4002;WZ-4002; | ||
| 分子式 | C25H27ClN6O3 | 分子量 | 494.99 |
| 生物活性 | WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR | ||
结构式
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