Kartogenin
| CAS号 | 4727-31-5 | 货号 | BCP09135 |
| 中文名 | Kartogenin | ||
| 英文名 | Kartogenin | ||
| 中文别名 | |||
| 英文别名 | KGN; 2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid; 2-[(4-phenylphenyl)carbamoyl]benzoic acid;4'-Phenylphthalanilic Acid; | ||
| 分子式 | C20H15NO3 | 分子量 | 317.34 |
| 生物活性 | Kartogenin is a small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program . KGN stimulated type-I collagen synthesis of fibroblasts at the mRNA and protein levels in a time-dependent manner, but KGN did not induce expression of α-skeletal muscle actin (α-sma) or matrix metallopeptidase1 (MMP1), MMP9 in vitro . KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4/smad5 pathway. | ||
| 信号通路 | TGF beta/Smad Wnt/Stem Cell | ||
| 靶 点 | TGF β/Smad | ||
结构式
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