NLG919
| CAS号 | 1402836-58-1 | 货号 | BCP09887 |
| 中文名 | NLG919 | ||
| 英文名 | NLG919 | ||
| 中文别名 | |||
| 英文别名 | GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078;IDO-IN-7; | ||
| 分子式 | C18H22N2O | 分子量 | 282.38 |
| 生物活性 | GDC-0919, also known as NLG919 and RG6078, is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, NLG919 targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | IDO | ||
结构式
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