SAR125844

  • 化学数据
CAS号 1116743-46-4 货号 BCP28183
中文名 SAR125844
英文名 SAR125844
中文别名
英文别名 SAR 125844; SAR-125844;
分子式 C25H23FN8O2S2 分子量 550.63
  • 用途
生物活性 SAR125844 is a potent and highly selective c-Met inhibitor with potential antineoplastic activity. Upon intravenous administration, SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. SAR125844 displayed nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and the M1250T and Y1235D mutants. Broad biochemical profiling revealed that SAR125844 was highly selective for MET kinase. SAR125844 inhibits MET autophosphorylation in cell-based assays in the nanomolar range, and promotes low nanomolar proapoptotic and antiproliferative activities selectively in cell lines with MET gene amplification or pathway addiction.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 c Met 

结构式

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