缬更昔洛韦
| CAS号 | 175865-60-8 | 货号 | BCP28511 |
| 中文名 | 缬更昔洛韦 | ||
| 英文名 | Valganciclovir | ||
| 中文别名 | |||
| 英文别名 | RS 079070-194; RO 107-9070/194; RS-79070-194; RS-079070-194; Ganciclovir L-valyl ester; | ||
| 分子式 | C14H22N6O5 | 分子量 | 354.36 |
| 生物活性 | Valganciclovir is an L-valyl ester (prodrug) of ganciclovir that exists as a mixture of two diastereomers. After oral administration, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of 2'-deoxyguanosine, which inhibits replication of human CMV in cell culture and in vivo. The reported EC50 values of ganciclovir that inhibit human CMV replication in cell culture (laboratory and clinical isolates) have ranged from 0.08 to 22.94 μM (0.02 to 5.75 mcg/mL). | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | CMV | ||
结构式
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