LY2606368
| CAS号 | 1234015-52-1 | 货号 | BCP14380 |
| 中文名 | LY2606368 | ||
| 英文名 | LY2606368 | ||
| 中文别名 | |||
| 英文别名 | LY 2606368;LY-2606368; Prexasertib; | ||
| 分子式 | C18H19N7O2 | 分子量 | 365.38 |
| 生物活性 | LY2606368 alone significantly inhibited the cell proliferation in a variety of pancreatic cell lines (SW1990, SU86.86, Bx-PC3, AsPC-1, CFPAC-1, Capan-2, HPAF-II) with SW1990 being the most sensitive (IC50=1.5 nM). LY2606368 has been reported to inhibit Chk1 auto-phosphorylation activated by DNA damaging agents, and induce phosphorylation of H2AX, a DNA damage maker in multiple cancer cell lines in vitro. In addition, LY2606368 has demonstrated potent single agent activity and potentiates the anti-tumor activity of DNA damaging agents in vivo. Pancreatic cancer is one of the least curable cancers, with an approximate 5% overall 5-year survival for all patients. In SW1990 pancreas orthotopic model, which represents the local and metastatic growth pattern seen in pancreas cancer patients, LY2606368 treatment resulted in over 92% inhibition of primary tumor growth as well as 100% inhibition of metastasis to lymph node, spleen and intestine. The anti-tumor effect of LY2606368 treatment was | ||
| 上下游产品 | 1234015-55-4（Prexasertib mesylate ） 1234015-54-3（ Prexasertib dihydrochloride） 1234015-57-6（Prexasertib Mesylate Hydrate） 1234015-58-7（Prexasertib dimesylate） | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Checkpoint | ||
结构式
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