维多氟拉迪莫
| CAS号 | 717824-30-1 | 货号 | BCP14555 |
| 中文名 | 维多氟拉迪莫 | ||
| 英文名 | Vidofludimus | ||
| 中文别名 | |||
| 英文别名 | 4SC 101; 4SC-101; 4SC101; SC12267; SC-12267; SC 12267; | ||
| 分子式 | C20H18FNO4 | 分子量 | 355.36 |
| 生物活性 | Vidofludimus, also known as 4SC 101 or SC12267, is a novel orally active and potent DHODH inhibitor. In vitro, 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes. In vivo, oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. 4SC-101 may have potential for the treatment of intestinal inflammation. Dihydroorotate dehydrogenase (DHODH) is a key enzyme involved in pyrimidine biosynthesis. DHODH is a known target for the treatment of autoimmune diseases. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Interleukin Related | ||
结构式
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