IGIG-929

CAS No.	51131-85-2	Cat. No.	BCP23684
Name	IGIG-929
Synonyms	9-Hydroxyellipticine; Hydroxyellipticine; 9-Hydroxyellipticin; NSC 210717; IGIG 929; IGIG929; LS133324; LS-133324; LS 133324;
Formula	C17H15ClN2O	M. Wt	298.77

Description	IGIG 929 is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines.
Pathways	Others Pathway
Targets	Others

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