O4I2
| CAS号 | 165682-93-9 | 货号 | BCP16032 |
| 中文名 | O4I2 | ||
| 英文名 | O4I2 | ||
| 中文别名 | |||
| 英文别名 | O4-I2;O4I 2; | ||
| 分子式 | C12H11ClN2O2S | 分子量 | 282.75 |
| 生物活性 | O4I2 activates Oct3/4 in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts. O4I2 activates also other pluripotencyassociated genes such as Lin28 and Nanog in a drug-like manner. O4I2 shows high activity in enforcing Oct3/4 expression. O4I2 activates Oct3/4 on the transcriptional and translational level in human fibroblasts. O4I2 promotes the expression of pluripotency-associated genes as analyzed by qRT-PCR in human neonatal foreskin fibroblasts (HFFs). O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 h treatment on the translational level. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Oct3/4 | ||
结构式
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