STF 083010

化学数据

CAS号	307543-71-1	货号	BCP16458
中文名	STF 083010
英文名	STF 083010
中文别名
英文别名	STF-083010;STF083010;
分子式	C15H11NO3S2	分子量	317.38

用途

生物活性	IC50 value: Target: Ire1 inhibitor in vitro: With the addition of STF-083010, splicing was almost completely blocked. STF-083010 also inhibited XBP1 splicing activated by other types of ER stress, including tunicamycin treatment, glucose deprivation, or severe hypoxia. in vivo: Treatment of these reporter mice with bortezomib induced ER stress and a commensurate increase in XBP1-luciferase bioluminescent activity. However, when STF-083010 was injected with bortezomib, there was no increase in bioluminescent signal. This inhibition was not the result of cellular toxicity in the animals, as we did not find any histologic effects of STF-083010 after treatment at doses used in these studies (60 mg/kg one time and 30 mg/kg 2 times.

生物活性

IC50 value: Target: Ire1 inhibitor in vitro: With the addition of STF-083010, splicing was almost completely blocked. STF-083010 also inhibited XBP1 splicing activated by other types of ER stress, including tunicamycin treatment, glucose deprivation, or severe hypoxia. in vivo: Treatment of these reporter mice with bortezomib induced ER stress and a commensurate increase in XBP1-luciferase bioluminescent activity. However, when STF-083010 was injected with bortezomib, there was no increase in bioluminescent signal. This inhibition was not the result of cellular toxicity in the animals, as we did not find any histologic effects of STF-083010 after treatment at doses used in these studies (60 mg/kg one time and 30 mg/kg 2 times.

结构式

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