Alda-1
| CAS号 | 349438-38-6 | 货号 | BCP17146 |
| 中文名 | Alda-1 | ||
| 英文名 | Alda-1 | ||
| 中文别名 | |||
| 英文别名 | Alda 1;Alda1; | ||
| 分子式 | C15H11Cl2NO3 | 分子量 | 324.16 |
| 生物活性 | in vitro: ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding. Alda-1 activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2. in vivo: Alda-1 inhibits atherosclerosis and attenuates NAFLD in apoE-/- mice. The treatment with Alda-1 results in a significant decrease of TG level in liver of apoE-/- mice. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ALDH | ||
结构式
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