贝利司他
| CAS号 | 866323-14-0 | 货号 | BCP24610 |
| 中文名 | 贝利司他 | ||
| 英文名 | Belinostat | ||
| 中文别名 | |||
| 英文别名 | PXD 101; PXD101; PXD-101; PX105684; PX-105684; PX 105684; | ||
| 分子式 | C15H14N2O4S | 分子量 | 318.37 |
| 生物活性 | Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. Belinostat was approved in 2014 for relapsed or refractory peripheral T-cell lymphoma. | ||
| 信号通路 | Cell Cycle/DNA Damage Epigenetics | ||
| 靶 点 | HDAC | ||
结构式
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