卢梭曲波帕
| CAS号 | 1110766-97-6 | 货号 | BCP18563 |
| 中文名 | 卢梭曲波帕 | ||
| 英文名 | Lusutrombopag | ||
| 中文别名 | 芦曲泊帕;鲁索曲波帕;卢曲波帕; | ||
| 英文别名 | S-888711; S 888711; S888711; | ||
| 分子式 | C29H32Cl2N2O5S | 分子量 | 591.55 |
| 生物活性 | Lusutrombopag, also known as S-888711, is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist being developed by Shionogi for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery. Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels. In September 2015, lusutrombopag received its first global approval in Japan for the improvement of CLD-associated thrombocytopenia in patients scheduled to undergo elective invasive procedures. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Others | ||
结构式
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