CCT245737
| CAS号 | 1489389-18-5 | 货号 | BCP18991 |
| 中文名 | CCT245737 | ||
| 英文名 | CCT245737 | ||
| 中文别名 | |||
| 英文别名 | CCT-245737;CCT 245737; | ||
| 分子式 | C16H16F3N7O | 分子量 | 379.34 |
| 生物活性 | In vitro: CCT245737 shows <50% inhibition at 10 μM for 85/121 kinases, representing a selectivity for CHK1 inhibition of >5000-fold over these enzymes. [1] CCT245737 enhanced gemcitabine antitumor activity to a greater degree than for higher doses of either agent alone, without increasing toxicity. In vivo: CCT2457374 shows an increase in plasma and tumoconcentrations between 3?100 mg/kg po. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Checkpoint | ||
结构式
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