常山酮氢溴酸盐

  • 化学数据
CAS号 64924-67-0 货号 BCP19376
中文名 常山酮氢溴酸盐
英文名 Halofuginone Hydrobromide
中文别名
英文别名 Halofuginone HBr; Halofuginone-HBr; HalofuginoneHBr;
分子式 C16H18Br2ClN3O3 分子量 495.59
  • 用途
生物活性 Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
信号通路 TGF beta/Smad  Wnt/Stem Cell 
靶 点 TGF β/Smad 

结构式

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