GSK321
| CAS号 | 1816331-63-1 | 货号 | BCP20143 |
| 中文名 | GSK321 | ||
| 英文名 | GSK321 | ||
| 中文别名 | |||
| 英文别名 | GSK-321;GSK 321; | ||
| 分子式 | C28H28FN5O3 | 分子量 | 501.22 |
| 生物活性 | GSK321 is a potent and selective IDH1 mutant inhibitor. GSK321 potently inhibited intracellular 2-HG production in HT-1080 cells, with a half-maximal effective concentration (EC50) of 85 nM by LC/MS/MS analysis. The inhibition of mutant IDH1 by GSK321 overcomes the pathognomonic differentiation block of AML cells and induces myeloid differentiation of IDH1 mutant cells at the level of leukemic blasts and more stem-like cells. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | IDH | ||
结构式
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