AZD8055富马酸
| CAS号 | 1201799-05-4 | 货号 | BCP25958 |
| 中文名 | AZD8055富马酸 | ||
| 英文名 | AZD8055 Fumaric acid | ||
| 中文别名 | |||
| 英文别名 | AZD8055 Fumarate;AZD-8055 Fumarate;AZD 8055 Fumarate; | ||
| 分子式 | C25H31N5O4.C4H4O4 | 分子量 | 581.62 |
| 生物活性 | AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. mTOR phosphorylates transcription factors, such as S6K1 and 4E-BP1, which stimulate protein synthesis and regulate cell growth, proliferation, motility, and survival. | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | mTOR | ||
结构式
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