Prima-1
| CAS号 | 5608-24-2 | 货号 | BCP26191 |
| 中文名 | Prima-1 | ||
| 英文名 | Prima-1 | ||
| 中文别名 | 2,2-二(羟基甲基)-1-氮杂双环[2,2,2]辛烷-3-酮; | ||
| 英文别名 | 2,2-Bis(Hydroxymethyl)-3-Quinuclidinone; 2,2-Dimethylolquinuclidin-3-One; | ||
| 分子式 | C9H15NO3 | 分子量 | 185.22 |
| 生物活性 | PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. | ||
| 信号通路 | Apoptosis Pathway Others Pathway | ||
| 靶 点 | Autophagy p53 | ||
结构式
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