SAICAR
| CAS No. | 3031-95-6 | Cat. No. | BCP28964 |
| Name | SAICAR | ||
| Synonyms | Succino-AICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate; | ||
| Formula | C13H19N4O12P | M. Wt | 454.28 |
| Description | SAICAR, also known as Succino-AICAR, is an intermediate in the de novo purine nucleotide synthesis pathway. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation. |
Structure
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