瑞普替尼
| CAS号 | 1442472-39-0 | 货号 | BCP29218 |
| 中文名 | 瑞普替尼 | ||
| 英文名 | Ripretinib | ||
| 中文别名 | |||
| 英文别名 | DCC 2618;DCC2618;KIT/PDGFR inhibitor;Ripretinib; | ||
| 分子式 | C24H21BrFN5O2 | 分子量 | 510.36 |
| 生物活性 | Ripretinib, also known as DCC-2618, is a potent, orally active and selective KIT/PDGFR inhibitor with potential antineoplastic activity. DCC-2618 targets and binds to both wild-type and mutant forms of KIT and PDGFRa specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. DCC-2618 also inhibits several other kinases, including vascular endothelial growth factor receptor type 2 (VEGFR2; KDR), angiopoietin-1 receptor (TIE2; TEK), PDGFR-beta and macrophage colony-stimulating factor 1 receptor (FMS; CSF1R), thereby further inhibiting tumor cell growth. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | PDGFR c Kit | ||
结构式
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