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Angiogenesis/Protein Tyrosine Kinase

结构式 货号 产品名称 CAS号
AZD-7451 结构式
BCP44112 AZD-7451 1079274-94-4
AZD7451 is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity
RN983 结构式
BCP44110 RN983 1423129-83-2
RN983 is a selective BTK enzyme inhibitor.
PF-06459988 结构式
BCP44108 PF-06459988 1428774-45-1
PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity.
c-Fms-IN-12 结构式
BCP44099 c-Fms-IN-12 1313407-95-2
c-Fms-IN-12 is a c-Fms inhibitor.
BIIB068 结构式
BCP44097 BIIB068 1798787-27-5
BIIB068 is a potent, selective, reversible and orally active BTK inhibitor.
JNJ-38877605 结构式
BCP44121 JNJ-38877605 943540-74-7
JNJ-38877618 is a hepatocyte growth factor receptor (HGFR; MET; c-Met) inhibitor potentially for the treatment of solid tumours.
Ilginatinib 结构式
BCP44119 Ilginatinib 1239358-86-1
Ilginatinib is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity. JAK2/Src inhibitor NS-018 competes with ATP for binding to JAK2 as well as the mutated form JAK2V617F, thereby inhibiting the activation of JAK2 and downstream molecules in the JAK2/STAT3 (signal transducer and activator of transcription 3) signaling pathway that plays an important role in normal development, particularly hematopoiesis. In addition, NS-018 inhibits the Src family tyrosine kinases. This eventually leads to the induction of tumor cell apoptosis.
SU4984 结构式
BCP44116 SU4984 186610-89-9
SU4984 is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM).
Vimseltinib 结构式
BCP44095 Vimseltinib 1628606-05-2
Vimseltinib, also known as DCC-3014, is a potent and orally active inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities.
Zabedosertib 结构式
BCP44094 Zabedosertib 1931994-81-8
Zabedosertib, also known as BAY 1834845, is a IRAK-4 inhibitor.
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