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基础原料

MAPK Pathway

结构式 货号 产品名称 CAS号
HPK1-IN-7 结构式
BCP43399 HPK1-IN-7 2320462-65-3
HPK1-IN-7 is a potent, orally active HPK1 inhibitor.
Vemurafenib 结构式
BCP43160 维罗非尼 1029872-54-5
Vemurafenib is a selective inhibitor of BRAF kinase that is used in the therapy of patients with metastatic and advanced malignant melanoma. Vemurafenib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe cases of clinically apparent acute liver injury.
Lifirafenib 结构式
BCP42783 Lifirafenib 1446090-79-4
Lifirafenib is a Novel potent and selective RAF Kinase and EGFR inhibitor.
MK2 Inhibitor III 结构式
BCP41255 MK2 Inhibitor III 724711-21-1
MK2 Inhibitor III is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis.
PF 3644022 结构式
BCP40723 PF 3644022 1276121-88-0
PF 3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (IC50 = 5.2 nM; Ki = 3 nM) with good selectivity when profiled against 200 human kinases.
CC-90001 结构式
BCP38621 CC-90001 1403859-14-2
CC-90001 is a potent and selective JNK inhibitor, which is 12.9-fold more potent for JNK1 inhibition than JNK2 in a cell-based model.
BAY-885 结构式
BCP34724 BAY-885 2307249-33-6
BAY-885 is a highly potent and selective ERK5 inhibitor.
Rineterkib 结构式
BCP38204 Rineterkib 1715025-32-3
Rineterkib is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway.
AZD7624 结构式
BCP37429 AZD7624 1095004-78-6
AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
trans-Zeatin Hydrochloride 结构式
BCP36686 反-玉米素盐酸盐 6025-81-6
trans-Zeatin Hydrochloride can be used in biological study and therapeutic use for plant-growth factors as cell-proliferating agents for promotion of wound healing.
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