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Smoothened/Smo

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Smoothened/Smo

结构式 货号 产品名称 CAS号
Saridegib 结构式
BCP25392 Saridegib 1037210-93-7
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
 结构式
XL139 mesylate 结构式
BCP23569 XL-139甲磺酸盐 XL139
BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity.
Jervine 结构式
BCP28214 介芬胺 469-59-0
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
GSA10 结构式
BCP24130 GSA10 300833-95-8
GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM).
SAG Hydrochloride 结构式
BCP26130 SAG盐酸盐 2095432-58-7
SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with Kd of 59 nM.
Smoothened Agonist HCl 结构式
BCP10857 Smoothened Agonist HCl 364590-63-6
Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened).
Halcinonide 结构式
BCP13695 哈西奈德 3093-35-4
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
Halcinonide 结构式
BCP18212 哈西奈德 3039-35-4
Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions.
MK-4101 结构式
BCP18385 MK-4101 935273-79-3
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
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