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Serine Protease

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Serine Protease

结构式 货号 产品名称 CAS号
Upamostat 结构式
 BCP46045 Upamostat 1191101-18-4
Upamostat is an orally bioavailable, 3-amidinophenylalanine-derived, second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. After oral administration, serine protease inhibitor WX-671 is converted to the active Nα-(2,4,6-triisopropylphenylsulfonyl)-3-amidino-(L)-phenyla lanine-4-ethoxycarbonylpiperazide (WX-UK1), which inhibits several serine proteases, particularly uPA; inhibition of uPA may result in the inhibition of tumor growth and metastasis.
Darexaban 结构式
 BCP45981 Darexaban 365462-23-3
Darexaban is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects.
BioE-1197 结构式
 BCP45917 BioE-1197 1268863-69-9
BioE-1197 showed similar specificity for PASK versus the same 50 protein kinases.
PF-06446846 结构式
 BCP43978 PF-06446846 1632250-49-7
PF-06446846 is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells.
PF-06446846 hydrochloride 结构式
 BCP43977 PF-06446846 hydrochloride 1632250-50-0
PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34.
3,4-Dichloroisocoumarin 结构式
 BCP36465 3,4-二氯-2-苯并吡喃-1-酮 51050-59-0
3,4-Dichloroisocoumarin is a serine protease inhibitor.
WNK-IN-11 结构式
 BCP32643 WNK-IN-11 2123489-30-3
WNK-IN-11 is a potent, selectiive and orally active inhibitor of WNK1 kinase.
BioE-1115 结构式
 BCP32544 BioE-1115 1268863-35-9
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.
Antipain, Dihydrochloride 结构式
 BCP30106 抗痛素二盐酸盐 37682-72-7
Antipain is a protease inhibitor found in Actinomycetes.
Gabexate mesylate 结构式
 BCP13557 甲磺酸加贝酯 56974-61-9
Gabexate Mesylate is a Factor X inhibitor.
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