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eIF

结构式 货号 产品名称 CAS号
Zotatifin 结构式
BCP35487 Zotatifin 2098191-53-6
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.
SBI-0640756 结构式
BCP31598 SBI-0640756 1821280-29-8
SBI-0640756 is a first-in-class inhibitor of eIF4G1, disrupting the eIF4F complex.
BTdCPU 结构式
BCP31242 BTdCPU 1257423-87-2
BTdCPU is an activator of HRI. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.
A 484954 结构式
BCP28798 A 484954 142557-61-7
A 484954 is a selective inhibitor of eEF2K with IC50 value of 0.28 μM.
SBI-0640756 结构式
BCP23633 SBI-0640756 SBI-0640756
SBI-0640756 is a water soluble inhibitor of eIF4G1 and disrupts the eIF4F complex.
Briciclib 结构式
BCP17292 布瑞西利 865783-99-9
Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
Sal003 结构式
BCP08928 Sal003 1164470-53-4
Sal003A is a potent cell-permeable analog of the eIF2α phosphatase inhibitor .
4E1RCat 结构式
BCP14974 4E1RCat 328998-25-0
4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
GCN2iB 结构式
BCP29510 GCN2iB 2183470-12-2
GCN2iB is an ATP-competitive GCN2 inhibitor, with an IC50 of 2.4 nM.
4EGI-1 结构式
BCP28021 4EGI-1 315706-13-9
4EGI-1 is an inhibitor of eIF4E:eIF4G interaction that acts by preventing eIF4E binding to eIF4G.
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