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结构式 货号 产品名称 CAS号
PF07104091 结构式
BCP42948 PF07104091 2460249-19-6
PF-07104091 is an orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity.
Venadaparib 结构式
BCP42946 Venadaparib 1681017-83-3
Venadaparib is an antineoplastic.Venadaparib is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
RGFP966 结构式
BCP42941 RGFP966 1396841-57-8
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.
RBN012759 结构式
BCP42877 RBN012759 2360851-29-0
RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.
OUN10989 HCl 结构式
BCP42739 OUN10989 HCl 915413-40-0
OUN10989, an analogue compound of LP-261, is a Potent Antimitotic Agent.
OUN10989 结构式
BCP42738 OUN10989 915410-98-9
OUN10989, an analogue compound of LP-261, is a Potent Antimitotic Agent.
SCR130 结构式
BCP42678 SCR130 2377858-38-1
SCR130 is a SCR7-based DNA nonhomologous end-joining (NHEJ) inhibitor.
LY3405105 结构式
BCP42676 LY3405105 2326428-25-3
LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8 nM. LY3405105 shows potential antineoplastic activity.
MS140 结构式
BCP42677 MS140 2229974-83-6
MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).
SB1317 结构式
BCP42651 SB1317 1204918-72-8
SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.
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